Triphenylphosphonium cation

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August undefined, 2024

WebOct 21, 2007 · Mitoquinone is targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of the large mitochondria membrane potential, the cations accumulate within cellular mitochondria up to 1,000 fold, compared to non-targeted antioxidants such as Coenzyme Q or its analogues, enabling the antioxidant … WebFeb 5, 2024 · As a lipophilic cation, triphenylphosphonium (TPP) has been commonly used in designing mitochondria‐targeted antioxidants. Conjugated with the TPP moiety, antioxidants can achieve more than 1000‐fold higher mitochondrial concentration depending on cell membrane potentials and mitochondrial membrane potentials. Herein we discuss …

Triphenylphosphonium (TPP)-Based Antioxidants: A New Perspective on

WebMay 1, 2008 · Abstract Mitochondria-targeted molecules comprising the lipophilic TPP (triphenylphosphonium) cation covalently linked to a hydrophobic bioactive moiety are used to modify and probe mitochondria in cells and in vivo. WebHere, we describe protocols dealing with the preparation, mitochondria permeation assessment, electron paramagnetic resonance (EPR) spin trapping setting, and antiapoptotic properties evaluation of a series of new linear nitrones vectorized by a triphenylphosphonium cation and labeled with a diethoxyphosphoryl moiety as 31 P … porin kesäteatterit

Lipophilic Triphenylphosphonium Cations Inhibit …

WebMay 11, 2024 · The lipophilic triphenylphosphonium cation is capable of accumulating in the mitochondrial matrix, proportionally to the difference in the potential present within the mitochondria, which makes it especially interesting to use in overactive mitochondria with increased potential, such as tumor cells ( Reily et al., 2013 ). WebThe hyperpolarized tumor cell membrane and mitochondrial membrane potential allow for selective accumulation of TPP + conjugates in tumor cell mitochondria versus those in normal cells. This could enhance direct killing of precancerous, dysplastic, and tumor cells while minimizing potential toxicities to normal cells. WebNov 30, 2024 · Triphenylphosphonium cation (TPP + ), a lipophilic cation, can easily pass through lipid bilayers due to its high lipophilicity and stable cationic charge, and the … porin keskusta kartta

Structure of phosphonium rhenates(VII) SpringerLink

Synthesis and Evaluation of 18F-Labeled Fluoroalkyl ...

WebTriphenylphosphonium Molecular Formula C H P Average mass 263.293 Da Monoisotopic mass 263.098419 Da ChemSpider ID 4410674 - Charge More details: Names Properties … WebAug 9, 2024 · Triphenylphosphonium-based modification of molecules facilitating mitochondria targeting is not a totally new concept as abundant literature already exists with regard to the potent biological effects exhibited by small molecules containing TPP +.28,32,33,40–44 Alkylated triphenylphosphonium cations initially were used as probes to … porin kierrätyskeskusWebApr 30, 2015 · Lipophilic cations based on the triphenylphosphonium moiety (TPP +) have been widely used to target various biologically active substances such as antioxidants … porin kierrätyskeskus savipajakatu pori

"WebConjugating conventional mitochondrial-targeted antioxidants, such as coenzyme Q10 or vitamin E, with the lipophilic triphenylphosphonium cation significantly increases the mitochondrial availability of these antioxidants, delivered as MitoQ or MitoVitE (Kalra, 2024). MitoQ (mitoquinone mesylate) was shown to penetrate to the IMM and improve ... " - Triphenylphosphonium cation

Triphenylphosphonium cation

Understanding and preventing mitochondrial oxidative damage

WebJun 13, 2024 · The first radiolabeled phosphonium cation studied for use in PET was [ 11 C]triphenylmethylphosphonium ( [ 11 C]TPMP ) [ 13 ]. [ 11 C]TPMP PET studies were performed to evaluate the membrane potential of heart tissue in canine models, which was determined to be 148.1 ± 6.0 mV (inside negative). WebJan 5, 2024 · The triphenylphosphonium cation was used as an efficient means for selective delivery of known anticancer agents such as doxorubicin (Han et al. 2014) and …

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WebMicelles Loaded With Puerarin And Modified With Triphenylphosphonium Cation Possess Mitochondrial Targeting And Demonstrate Enhanced Protective Effect Against Isoprenaline-Induced H9c2 Cells Apoptosis

WebNov 30, 2024 · Here we present a method for identification of PEPSs, and show that conjugation with mitochondria-targeting triphenylphosphonium cation (TPP +) can enhance or restore the compounds' antifungal activity. WebLipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology.

WebFeb 23, 2007 · The cations lie in general positions except for A where the 1,2-bis (triphenylphosphonium)ethane cation lies at the centre of symmetry. It seems that for all the cations the description of the triphenylphosphonium moiety conformation (-PPh 3) the model reported by Dance & Scudder 14 could be useful. WebNov 22, 2012 · Mitochondria play key roles in a broad range of biomedical situations, consequently there is a need to direct bioactive compounds to mitochondria as both therapies and probes. A successful approach has been to target compounds to mitochondria by conjugation to lipophilic cations, such as triphenylphosphonium (TPP), …

WebApr 15, 2003 · Because alkyltriphenylphosphonium cations pass easily through lipid bilayers by non-carrier-mediated transport, they should be taken up by the mitochondria of all …

WebWe present an optimized procedure for synthesis of three [ 18 F]-labeled fluoroalkyl triphenylphosphoniumTriphenylphosphonium (TPP) salts ( [ 18 F]FATPs) via two-step … porin kirjasto aineistohakuWebThus, the triphenylphosphonium functional group should be considered for the development of photoantimicrobials for the selective killing of Gram-positive bacteria in the presence of … porin kirjakauppaWebOne way to do this is to invent antioxidants that are selectively accumulated into mitochondria within patients. Such mitochondria-targeted antioxidants have been developed by conjugating the lipophilic triphenylphosphonium cation to an antioxidant moiety, such as ubiquinol or α-tocopherol. porin kirjakauppa oyWebOne way to do this is to invent antioxidants that are selectively accumulated into mitochondria within patients. Such mitochondria-targeted antioxidants have been … porin kirjastoWebOct 19, 2016 · The lipophilic triphenylphosphonium cation (TPP) has been the most widely used to direct a range of moieties to mitochondria in vivo, including redox probes, antioxidants and spin traps [ 2, 4, 5 ]. The TPP moiety is relatively easy to introduce into a compound by displacing a leaving group by reaction with triphenylphosphine [ 6 ]. porin kirjasto lainojen uusintaWebJun 2, 2011 · Triphenyl phosphonium cations (TPPs) are delocalized lipophilic cations that accumulate in the mitochondria of cells. We have explore the effect of increasing the … porin kirjasto varausWebOct 1, 2024 · Triphenylphosphonium (TPP) cations have been used for the development of tumor or myocardial diagnostic radiopharmaceuticals. In this work, the development of … porin kirjasto omat lainat