Group sequential weighted holm procedure
http://users.iems.northwestern.edu/~ajit/papers/56)%20Allocating%20recycled%20significance%20levels%20in%20group%20sequentialprocedures%20for%20multiple%20endpoints.pdf In statistics, the Holm–Bonferroni method, also called the Holm method or Bonferroni–Holm method, is used to counteract the problem of multiple comparisons. It is intended to control the family-wise error rate (FWER) and offers a simple test uniformly more powerful than the Bonferroni … See more When considering several hypotheses, the problem of multiplicity arises: the more hypotheses are checked, the higher the probability of obtaining Type I errors (false positives). The Holm–Bonferroni method is one of many … See more Holm–Šidák method When the hypothesis tests are not negatively dependent, it is possible to replace See more Carlo Emilio Bonferroni did not take part in inventing the method described here. Holm originally called the method the "sequentially … See more The method is as follows: • Suppose you have $${\displaystyle m}$$ p-values, sorted into order lowest-to-highest $${\displaystyle P_{1},\ldots ,P_{m}}$$, and their corresponding hypotheses $${\displaystyle H_{1},\ldots ,H_{m}}$$（null … See more The Holm–Bonferroni method is "uniformly" more powerful than the classic Bonferroni correction, meaning that it is always at least as powerful. There are other methods for controlling the FWER that are more powerful than Holm–Bonferroni. … See more
Group sequential weighted holm procedure
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WebFeb 1, 2008 · Together with a general weighting scheme W , the proposed weighted parametric test (1) and (2) includes many procedures in the literature as special cases, such as the step-down Dunnett procedure ... WebJul 1, 2003 · A variety of weighted Bonferroni-based test procedures have been proposed, for example, the weighted or unweighted Bonferroni-Holm procedure [Holm, 1979], fixed sequence tests [Westfall and ...
WebFamily 2: Holm test Gatekeeping procedure 2 Family 1: Truncated Hochberg test with truncation parameter of 0.7 Family 2: Hochberg test. C: Performance Quintiles … WebDec 10, 2024 · The trial uses a group sequential design with an interim and a final analysis. When the information times at the interim analysis are the same for the primary and the secondary hypotheses, it...
WebMar 18, 2024 · Pragmatic methods for design and analysis of weighted parametric group sequential design (WPGSD) under closed testing procedures are proposed to maintain the strong control of familywise... WebNov 18, 2024 · Two procedures are proposed based on weighted p-values, where the weights for p-values are obtained by maximizing a power-related objective function. We find that the proposed procedures can...
WebAug 12, 2011 · Group sequential design (GSD) is widely used in clinical trials in which correlated tests of multiple hypotheses are used. ... tests that can handle up to a thousand endpoints and has higher power for each individual hypothesis than the weighted Holm procedure, especially when the correlation between endpoints is high. Expand. 21. …
WebHolm's procedure uses the same critical values as Hochberg's procedure, namely c (i)=alpha/ (m-i+1), but is a step-down version while Hochberg's method is a step-up … other use for viagraWebJ-STAGE Home other user not available windows 10WebJul 1, 2024 · We review several group sequential Holm (GSHM) type procedures proposed in the literature and clarify the relationships between them. In particular, we … rocking newbornWebgroup sequential Holm multiple primary hypotheses precision medicine correlated test statistics overrunning cardiovascular oncology Acknowledgments We would like to thank … other user option not popping upWebmatic methods for design and analysis of weighted parametric group sequential design (WPGSD) under closed testing procedures are proposed to maintain the strong control … other users don\u0027t show in win 10WebSequential / group sequential clinical trials. Interim analysis (Flector trial: stop for futility) Sequential clinical trials always have a restriction on the maximum number of sampled … rocking news years liveWebFeb 28, 2014 · Specifically, we extend the Holm procedure for serial gatekeeping structured hypotheses in adaptive clinical trials. The proposed approach is based on the idea of combining partition testing with the inverse normal combination test. A clinical trial example is used to illustrate the implementation of the proposed procedure. rocking new years 2023