Cytoprotective mechanisms
WebCellular protection was determined in terms of cell viability, glyoxalase I and glutathione s-transferases activities, and carboxymethyl lysine (CML) and malondialdehyde levels. Our … WebMay 26, 2011 · Numerous publications have reported cytoprotective mechanisms that cancer cells exploit to avoid the cytotoxic effects of PDT. 26 The first mechanism identified was based on the large variation observed in the level of antioxidant molecules expressed in cancer cells. 39 Both water-soluble antioxidants (eg, some amino acids, glutathione …
Cytoprotective mechanisms
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A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal protection. Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible to injury. Gastric cytoprotective drugs include carbenoxolone, … WebThe paradigm developed on the premise that autophagy is cytoprotective in nature has provided the rationale for current clinical trials designed with the goal of radiosensitizing cancer cells through the use of autophagy inhibitors; however, these have failed to produce consistent results.
Young adult animals were exposed to mild oxidation (1 mM Fe2+, 1 h), fasting (8 h without food), heat (35 °C, 20 min), or transient … See more Lifespan studies were performed at 20 °C on NGM plates (BactoAgar: BritaniaLab, Argentina or Becton Dickinson, USA) with OP50 as a food … See more Young adult worms were exposed to oxidative stress or heat stress and to a repeated acute stress (tapping plates or light pulse) simultaneously. Survival was evaluated and a survival curve or SI was calculated for each … See more Mobility was assessed at days 4, 7 and 10 of adulthood. To evaluate mobility, 10 worms were transferred to an unseeded NMG plate into a drop of M9 buffer. Once the drop had dried, worms were left to acclimatize for 2–3 … See more WebApr 14, 2024 · The cytoprotective effects of LPM were tested on HepG2 cells. A total of 66 diverse metabolites were identified in LPM, among which saturated fatty acids, amino acids and dicarboxylic acids were highly enriched. LPM attenuated cell damage, lipid peroxidation and the levels of intracellular cytoprotective enzymes in H 2 O 2 -treated cells.
WebJul 20, 2024 · We identified two mechanisms for the cytoprotective effects of endogenous H2S: 1) stimulating the expression of enzymatic antioxidant systems and 2) promoting the activity of catalases, especially KatB, at the post-translational level. WebApr 21, 2024 · Moreover, EP4 and EP5 could significantly protect human umbilical vein endothelial cells (HUVECs) from H 2 O 2 -induced oxidative damage by increasing the levels of antioxidant enzyme systems including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) to reduce the levels of reactive oxygen species (ROS) (60.51 and …
WebJan 20, 2012 · In conclusion, this study demonstrated that autophagy acts as a cytoprotective mechanism against UV-induced apoptosis and that autophagy induction accompanied with apoptosis at late stages is independent of ATR activation. Keywords: autophagy; apoptosis; UV 1. Introduction
WebApr 14, 2024 · Owing to the cytoprotective function of autophagy, it serves to suppress tumorigenesis in terms of cancer initiation. Indeed, an elevated gene signature for autophagy is observed in healthy mammary glands, which is found to be decreased as breast cancer progresses [ 44 ]. how many acres is 3900 square feetWebDec 23, 2024 · Such mechanisms include the selective elimination of particularly radiosensitive cell types and consequent loss of specific cellular functions, the local release of cytokines and danger signals... high networth individuals in indiaWebAug 1, 2016 · Three well-known mechanisms regulate cytoprotective enzymes including Nrf2-, FOXO-, and sirtuin-dependent mechanisms. Several reports have indicated a … high neut countWebThe flight response activates neurons that release tyramine, an invertebrate analogue of adrenaline and noradrenaline. Tyramine stimulates the insulin-IGF-1 signalling (IIS) … how many acres is 3500 sq ftWebCytoprotective, radioprotective Mechanism of Action An antineoplastic adjunct and cytoprotective agent that is converted to an active metabolite by alkaline phosphatase … how many acres is 3920 sq ftWebUnsaturated lipids in cell membranes, including phospholipids and cholesterol, are well-known targets of oxidative modification, which can be induced by a variety of … how many acres is 4200 sq ftWebMar 1, 2024 · Cytoprotective mechanisms are activated through upregulation of the expression of NTs and growth molecules that integrate neuroplastic and proliferative … high networth individuals in south africa