Cisplatin hearing loss data
WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by … WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to …
Cisplatin hearing loss data
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WebAfter the cisplatin treatment marked hearing loss were detected, with ABR thresholds increasing to 34.5 ± 16.1 dB, 40.8 ± 16.7 dB, and 43.7 ± 18.2 dB at 8, 16, and 32 kHz, respectively. NS, normal saline; dB, decibel; ABR, auditory brainstem response. 2.2. Auditory Brainstem Response (ABR) WebFeb 24, 2024 · Cisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of …
WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … WebThirteen percent sustained a significant hearing handicap. An interindividual variation was found, ranging from severe hearing loss after the first course to unaffected hearing after …
WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease … WebAug 31, 2016 · Ototoxicity poses a major problem to the cancer patient, as the quality of life after receiving cisplatin chemotherapy may be negatively affected due to hearing loss, resulting in social, emotional, and vocational difficulties, as effective communication is …
WebFeb 15, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not …
WebLovastatin protects against cisplatin-induced hearing loss in mice. Cisplatin is used to treat a variety of solid tumors in both children and adults. However, cisplatin has serious … how to shoot lightning minecraft bedrockWebSigns and symptoms seen in children as ototoxicity develops include: High-frequency (≥4 kHz) sensorineural hearing loss that is bilateral (affecting both sides), progressive, and … how to shoot left handedWebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is … how to shoot lifestyle photographyWebTaking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10(-8), hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, how to shoot like a navy seal free downloadWebJul 2, 2024 · Caffeine pre-treatment further reduced wave I and II amplitudes, suggesting worsening of cisplatin-induced hearing loss. The data is plotted as mean ± SEM (n ≥ 6). Asterisks, * p < 0.05 vs.... how to shoot lightningWebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … nottingham building society louthWebDec 11, 2024 · It is used for the treatment of a variety of cancers such as cervical, breast, stomach, prostate, bladder and oesophageal, to name a few. However due to its expansive toxicity profile, patients receiving cisplatin can experience high frequency hearing loss, a side effect known as ototoxicity. nottingham building society lms